Kinase Profiling
Protein kinases are key regulators of important cellular processes, including growth, stress response, differentiation and apoptosis. About 550 kinases have been identified in the human genome, exerting their functions inside the cell in complex networks. For drug development , signal transduction research and clinical research in-depth insight in the effects of stimuli on multiple protein kinases is often required in order to fully understand the effects of kinase inhibitors, disease development or growth factor stimuli. The PepChip Kinase Profiling products provide this broad view on kinase changes by analyzing kinase activities in cells and tissues on up to 1,184 unique substrates on a single microarray. The low sample volume required allows analysis of biopsies, sections, and white blood cell samples, as well as cultured cells and tumor material.