Recent Literature

Epitope Mapping

Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies. 2011. Niederfellner G, Lammens A, Mundigl O, Georges GJ, Schaefer W, Schwaiger M, Franke A, Wiegmann K, Jenewein S, Slootstra JW, Timmerman P, Brännström A, Lindstrom F, Mössner E, Umana P, Hopfner K-P, Klein C. Blood 118:358-367. Link to Abstract.

Chlamydia pneumonia CdsL regulates CdsN ATPase activity, and disruption with a peptide mimetic prevents bacterial invasion. 2011. Stone CB, Bulir DC, Emdin CA, Pirie RM, Porfilio EA, Slootstra JW, Mahony JB. Frontiers in Microbiology, 2:1-9. Link to Abstract. Link to Free Full Text.

The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20. 2006. Teeling JL, Mackus WJM, Wiegman LJJM, Brakel JHN van den, Beers SA, French RR, Meerten T van, Ebeling S, Vink T, Slootstra JW, Parren PWHI, Glennie MJ, Winkel JGJ van de. Journal of Immunology 177: 362-371. Link to Abstract. Link to Free Full Text

CLIPS technology

Helical peptide arrays for lead identification and interaction site mapping. 2011. Langedijk JP, Zekveld MJ, Ruiter M, Corti D, Back JW. Analytical Biochemistry 417(1):149-55. Link to Abstract. 

Functional reconstruction of structurally complex epitopes using CLIPSTM technology. 2009. Timmerman P, Puijk WC, Boshuizen RS, van Dijken P, Slootstra JW, Beurskens FJ, Parren PWHI, Huber A, Bachmann MF, Meloen RH. Open Vaccine Journal 2:56-67. Link to Abstract. Link to Free Full Text.

Mapping of a discontinuous and highly conformational binding site on follicle stimulating hormone subunit-ß (FSH-ß) using domain scan and matrix scan technology. Timmerman P, van Dijk E, Puijk W, Schaaper W, Slootstra JW, Carlisle SJ, Coley J, Eida S, Gani M., Hunt T, Perry P, Piron G, Meloen RH. 2004.  Molecular Diversity 8:61-77. Link to Abstract.

Peptide Chip

Kinome Profiling of Clinical Cancer Specimens.Parikh K, Peppelenbosch MP, 2010. Kinome Profiling of Clinical Cancer Specimens. Cancer Research 70:2575-2578. Link to Abstract. Link to Free Full Text.

Kinome profiling of chondrosarcoma reveals SRC-pathway activity and dasatinib as option for treatment. 2009. Schrage YM, Briaire-de Bruijn IH, de Miranda NF, van Oosterwijk J, Taminiau AH, van Wezel T, Hogendoorn PC, Bovée JV. Cancer Research. 69:6216-22. Link to Abstract. Link to Free Full Text.

Peptide Microarray Analysis of Substrate Specificity of the Transmembrane Ser/Thr Kinase KPI-2 Reveals Reactivity with Cystic Fibrosis Transmembrane Conductance Regulator and Phosphorylase. 2006. Hong Wang and David L. Brautigan. Molecular & Cellular Proteomics 5:2124-2130. Link to Abstract. Link to Free Full Text.

A comprehensive list of manuscripts can be found here: http://www.pepscan.com/therapeutics/technology/key-literature/