The peptide synthesis team of Pepscan can apply a wide range of C‑terminal modifications. The default C-terminus of a peptide is either a free carboxylic acid or an amide. C-terminal amidation removes the charge form the C-terminus of a peptide. This may reduce the overall solubility of the peptide. The uncharged C-terminal amide end more closely mimics the native protein, and therefore may increase the biological activity of a peptide. It also tends to increase the stability, and prolongs their shelf life.
Frequently applied C-terminal modifications are shown in the table below.