C-terminal modifications

Pepscan (now Biosynth B.V.) is part of Biosynth's Peptide Division. This page will soon be fully integrated into the Biosynth website. Visit www.biosynth.com and bookmark it.

You can find everything about C-terminal modifications here.

The peptide synthesis team of Pepscan can apply a wide range of C‑terminal modifications. The default C-terminus of a peptide is either a free carboxylic acid or an amide.

C-terminal amidation

C-terminal amidation removes the charge form the C-terminus of a peptide. This may reduce the overall solubility of the peptide. The uncharged C-terminal amide end more closely mimics the native protein, and therefore may increase the biological activity of a peptide. It also tends to increase the stability, and prolongs their shelf life.

Frequently applied C-terminal modifications are shown in the table below.

Amides (NH2)

Amide

N-alkyl amides

nmenet

Aldehydes

Aldehyde

Esters

Oet Ome

p-Nitroanilide (pNA)

Pna

7-Amino-4-Methylcoumarin (AMC)

Amc

Our C-terminal modification options are not limited to the ones listed below. Additional modifications are available upon request, please inquire here.

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