C-terminal modifications

The peptide synthesis team of Pepscan can apply a wide range of C‑terminal modifications. The default C-terminus of a peptide is either a free carboxylic acid or an amide.

C-terminal amidation

C-terminal amidation removes the charge form the C-terminus of a peptide. This may reduce the overall solubility of the peptide. The uncharged C-terminal amide end more closely mimics the native protein, and therefore may increase the biological activity of a peptide. It also tends to increase the stability, and prolongs their shelf life.

Frequently applied C-terminal modifications are shown in the table below.

Amides (NH2)

Amide

N-alkyl amides

nmenet

Aldehydes

Aldehyde

Esters

Oet Ome

p-Nitroanilide (pNA)

Pna

7-Amino-4-Methylcoumarin (AMC)

Amc

Our C-terminal modification options are not limited to the ones listed below. Additional modifications are available upon request, please inquire here.

We use cookies to ensure that we give you the best experience on our website. We also use cookies to ensure we show you advertising that is relevant to you. If you continue without changing your settings, we’ll assume that you are happy to receive all cookies on the Pepscan website. However, if you would like to, you can change your cookie settings at any time in your browser.
Cookie Policy
Find out more
Accept All Cookies
By continuing to browse or by clicking "Accept All Cookies" you agree to the storing of first and third-party cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts.
Cookie Policy
Cookie Settings
Accept All Cookies