Metal Chelators / Radioligands
Molecular imaging has become an indispensable tool in modern diagnostics in biomedical research and therapeutic fields. Modern imaging techniques increasingly rely on the use of radioactive isotopes of certain metal ions, often in combination with targeting peptides.
Custom synthesis of such peptide conjugates, in which a chelating agent is covalently linked to the peptide, is also available at Pepscan. The modifications can be made at the N-terminus or at the C-terminus via a C-terminal lysine. These conjugates are able to give very stable complexes of many metals or with radioactive isotopes of metals currently used in Nuclear Medicine (In-111, Y-90,Tc-99m, Lu-177, Ga-68).
Pepscan routinely applies a variety of chelating agents, such DOTA, DTPA, NOTA and TETA.
Selected references for Metal Chelator peptides
Nielsen et al: Nucl. Med. Biol (2016) – PMID 27474962. (68)Ga-labeled phage-display selected peptides as tracers for positron emission tomography imaging of Staphylococcus aureus biofilm-associated infections: Selection, radiolabelling and preliminary biological evaluation.
Need a quote?
Please fill out a quote request form. One of our experts will be in contact with you shortly.
Request a quote
-
- N-terminal modifications
- C-terminal modifications
- Unusual & Non-natural Amino Acids
- Biotinylation
- Carrier conjugation
- Fatty acid conjugation
- Cyclizations
- CLIPS cyclization
- Cyclization with multiple S-S bonds
- Peptide PEGylation
- Sulphation
- Phosphorylation
- Prenylation
- Linkers & spacers
- Metal Chelators / Radioligands
- Fluorescently labeled peptides
- Quenched fluorescent peptides
- Tagged peptides
- Stable isotope labeled peptides
- Cell penetrating peptides
- Long peptides