N-terminal modifications
Chemically synthesized peptides have free amino-terminal. Via N-terminal acetylation the charge is removed from the amino terminus of a peptide. Generally, acetyl modification is recommended to make the peptide more closely mimic the charge state in the native protein. In addition this modification stabilizes the resulting peptide, and enhances their ability to resist enzymatic degradation by exopeptidases.
A multitude of N-terminal modifications can be applied by Pepscan’s peptide synthesis experts. Frequently applied N-terminal modifications are listed in the table below.
Acetyl
Formyl
Pyroglutamyl (pGlu)
Fatty acids
Urea
Carbamate
Sulfonamide
Alkylamine
Our N-terminal modification options are not limited to the ones listed. Additional modifications are available upon request, please inquire here.
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- N-terminal modifications
- C-terminal modifications
- Unusual & Non-natural Amino Acids
- Biotinylation
- Carrier conjugation
- Fatty acid conjugation
- Cyclizations
- CLIPS cyclization
- Cyclization with multiple S-S bonds
- Peptide PEGylation
- Sulphation
- Phosphorylation
- Prenylation
- Linkers & spacers
- Metal Chelators / Radioligands
- Fluorescently labeled peptides
- Quenched fluorescent peptides
- Tagged peptides
- Stable isotope labeled peptides
- Cell penetrating peptides
- Long peptides
