Prenylation
Protein prenylation involves the addition of a farnesyl (C15) or geranylgeranyl (C20) isoprenoid moiety onto a cysteine residue located near the carboxyl terminal of a protein. This posttranslational modification occurs at the C-terminus of approximately 2% of all mammalian proteins. Different classes of proteins, among them the family of Ras proteins, are known to be farnysylated. Prenylation is an important process to mediate protein-protein interactions and protein-membrane interactions. A recently discovered application of prenylated peptides is that they have inherent cell-penetrating ability.
Prenylation of peptides requires the addition of a lipid chain formed by three (farnesyl) or 4 (geranylgeranyl) isoprene units to a free thiol group. The synthesis of peptides containing farnesyl or geranylgeranyl groups is severely hampered by the pronounced acid-lability of these groups, in particular of the double bonds which are all transconfigured in the farnesyl and geranylgeranyl chains. Pepscan has developed a reliable procedure for the synthesis of prenylated peptides, and therefore is able supply these peptides at the request of its customers.
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- N-terminal modifications
- C-terminal modifications
- Unusual & Non-natural Amino Acids
- Biotinylation
- Carrier conjugation
- Fatty acid conjugation
- Cyclizations
- CLIPS cyclization
- Cyclization with multiple S-S bonds
- Peptide PEGylation
- Sulphation
- Phosphorylation
- Prenylation
- Linkers & spacers
- Metal Chelators / Radioligands
- Fluorescently labeled peptides
- Quenched fluorescent peptides
- Tagged peptides
- Stable isotope labeled peptides
- Cell penetrating peptides
- Long peptides