C-terminal modifications

The peptide synthesis team of Pepscan can apply a wide range of C‑terminal modifications. The default C-terminus of a peptide is either a free carboxylic acid or an amide.

C-terminal amidation

C-terminal amidation removes the charge form the C-terminus of a peptide. This may reduce the overall solubility of the peptide. The uncharged C-terminal amide end more closely mimics the native protein, and therefore may increase the biological activity of a peptide. It also tends to increase the stability, and prolongs their shelf life.

Frequently applied C-terminal modifications are shown in the table below.

Amides (NH2)


N-alkyl amides





Oet Ome

p-Nitroanilide (pNA)


7-Amino-4-Methylcoumarin (AMC)


Our C-terminal modification options are not limited to the ones listed below. Additional modifications are available upon request, please inquire here.

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