C-terminal modifications
The peptide synthesis team of Pepscan can apply a wide range of C‑terminal modifications. The default C-terminus of a peptide is either a free carboxylic acid or an amide.
C-terminal amidation removes the charge form the C-terminus of a peptide. This may reduce the overall solubility of the peptide. The uncharged C-terminal amide end more closely mimics the native protein, and therefore may increase the biological activity of a peptide. It also tends to increase the stability, and prolongs their shelf life.
Frequently applied C-terminal modifications are shown in the table below.
Amides (NH2)
N-alkyl amides
Aldehydes
Esters
p-Nitroanilide (pNA)
7-Amino-4-Methylcoumarin (AMC)
Our C-terminal modification options are not limited to the ones listed below. Additional modifications are available upon request, please inquire here.
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